Mitochondrial DNA in extracellular vesicles declines with age
S Lazo, N Noren Hooten, J Green, E Eitan… - Aging cell, 2021 - Wiley Online Library
The mitochondrial free radical theory of aging suggests that accumulating oxidative damage
to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating …
to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating …
Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density
Epigenetic modification through DNA methylation is implicated in metabolic disease. Using
whole-genome promoter methylation analysis of skeletal muscle from normal glucose …
whole-genome promoter methylation analysis of skeletal muscle from normal glucose …
Advances in forensic DNA quantification: a review
This review focuses upon a critical step in forensic biology: detection and quantification of
human DNA from biological samples. Determination of the quantity and quality of human …
human DNA from biological samples. Determination of the quantity and quality of human …
PCR-based analytical methods for quantification and quality control of recombinant adeno-associated viral vector preparations
AA Shmidt, TV Egorova - Pharmaceuticals, 2021 - mdpi.com
Recombinant adeno-associated viral vectors (rAAV) represent a gene therapy tool of ever-
increasing importance. Their utilization as a delivery vehicle for gene replacement, silencing …
increasing importance. Their utilization as a delivery vehicle for gene replacement, silencing …
Comparison and optimization of ancient DNA extraction
N Rohland, M Hofreiter - Biotechniques, 2007 - Taylor & Francis
Ancient DNA analyses rely on the extraction of the tiny amounts of DNA remaining in
samples that are hundreds to tens of thousands of years old. Despite the critical role …
samples that are hundreds to tens of thousands of years old. Despite the critical role …
[图书][B] Forensic biology: identification and DNA analysis of biological evidence
R Li - 2008 - taylorfrancis.com
Designed as an accessible introduction to basic scientific principles and their application in
professional practice, Forensic Biology provides a concise overview of the field. Focusing …
professional practice, Forensic Biology provides a concise overview of the field. Focusing …
Mystery solved: the identification of the two missing Romanov children using DNA analysis
One of the greatest mysteries for most of the twentieth century was the fate of the Romanov
family, the last Russian monarchy. Following the abdication of Tsar Nicholas II, he and his …
family, the last Russian monarchy. Following the abdication of Tsar Nicholas II, he and his …
Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos
It has not been possible to generate naïve human pluripotent stem cells (hPSCs) that
substantially contribute to mouse embryos. We found that a brief inhibition of mTOR with …
substantially contribute to mouse embryos. We found that a brief inhibition of mTOR with …
Evaluation of saliva as a source of human DNA for population and association studies
D Quinque, R Kittler, M Kayser, M Stoneking… - Analytical …, 2006 - Elsevier
A simple noninvasive procedure for saliva sample collection and DNA extraction was
developed. On average, the amount of human DNA (as measured by a TaqMan-based …
developed. On average, the amount of human DNA (as measured by a TaqMan-based …
A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis
The human oxidative phosphorylation (OxPhos) system consists of approximately 90
proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular …
proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular …