We have recently proposed a new model for understanding how tumors evolve. To achieve
successful" Tumor-Stroma Co-Evolution", cancer cells induce oxidative stress in adjacent …

Cancer cells show a broad spectrum of bioenergetic states, with some cells using aerobic
glycolysis while others rely on oxidative phosphorylation as their main source of energy. In …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis …

Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells
induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the …

We have recently proposed a new mechanism for explaining energy transfer in cancer
metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting …

Brain metastases are difficult to treat and mostly develop late during progressive metastatic
disease. Patients at risk would benefit from the development of prevention and improved …

Previously, we proposed that cancer cells behave as metabolic parasites, as they use
targeted oxidative stress as a “weapon” to extract recycled nutrients from adjacent stromal …

Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism
remains largely unknown. An important clue comes from recent studies linking autophagy …

In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, which states that
cancer cells (the seeds) need the proper microenvironment (the soil) for them to grow …