The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants
at the chromosome 1q31. 3 encompassing the complement factor H (CFH, FH) and CFH …

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

Dense deposit disease (DDD) is a severe renal disease characterized by accumulation of
electron-dense material in the mesangium and glomerular basement membrane. Previously …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH …

Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed
world. It is a complex multifactorial disease, and despite new advances in treatment, many …

Recognition and removal of apoptotic and necrotic cells must be efficient and highly
controlled to avoid excessive inflammation and autoimmune responses to self. The …