Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Tight control of cell fate choices is crucial for normal development. Here we show that lamin
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …

Generation of widely differing and specialized cell types from a single totipotent zygote
involves large-scale transcriptional changes and chromatin reorganization. Pioneer …

Large intergenic non-coding RNAs (lincRNAs) play widespread roles in epigenetic
regulation during multiple differentiation processes, but little is known about their mode of …

Gene regulatory networks controlling functional activities of spatially and temporally distinct
endodermal cell populations in the early mouse embryo remain ill defined. The T-box …

Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …