Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies

S Thomson, CA Hamilton, JC Hope, F Katzer… - Veterinary …, 2017 - Springer
Gastrointestinal disease caused by the apicomplexan parasite Cryptosporidium parvum is
one of the most important diseases of young ruminant livestock, particularly neonatal calves …

Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

SM Khan, WH Witola - Frontiers in cellular and infection microbiology, 2023 - frontiersin.org
The intracellular protozoan parasite of the genus Cryptosporidium is among the leading
causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is …

Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy

N Caldwell, C Peet, P Miller, BL Colon… - Science Translational …, 2024 - science.org
Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp.
parasites and is a leading cause of death in malnourished children worldwide. The only …

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

J Ajiboye, JE Teixeira, M Gasonoo, EB Mattice… - Nature …, 2024 - nature.com
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in
children and immunocompromised people. There is only one approved treatment that is …

Toxoplasmosis: Current and emerging parasite druggable targets

RE Hajj, L Tawk, S Itani, M Hamie, J Ezzeddine… - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a prevalent disease affecting a wide range of hosts including
approximately one-third of the human population. It is caused by the sporozoan parasite …

Promising Drug Targets and Compounds with Anti-Toxoplasma gondii Activity

M Silva, C Teixeira, P Gomes, M Borges - Microorganisms, 2021 - mdpi.com
Toxoplasmosis is a parasitic disease caused by the globally distributed protozoan parasite
Toxoplasma gondii, which infects around one-third of the world population. This disease …

Novel treatment strategies and drugs in development for cryptosporidiosis

MA Chavez, AC White Jr - Expert Review of Anti-Infective Therapy, 2018 - Taylor & Francis
Introduction: Cryptosporidium is a protozoan pathogen that can cause diarrheal disease in
healthy and immunosuppressed individuals, worldwide. Recent studies have highlighted the …

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

R Choi, MA Hulverson, W Huang, RSR Vidadala… - International journal for …, 2020 - Elsevier
Abstract Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in
apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for …

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

CS Lunde, EE Stebbins, RS Jumani, MM Hasan… - Nature …, 2019 - nature.com
Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children and
causes chronic diarrhea in AIDS patients, but the only approved treatment is ineffective in …

Emerging therapeutic avenues against Cryptosporidium: A comprehensive review

M Ali, C Xu, MFA Kulyar, K Li - Veterinary Parasitology, 2024 - Elsevier
Cryptosporidium is among the top causes of life-threatening diarrheal infection in public
health and livestock sectors. Despite its high prevalence and economic importance …