The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

Spontaneous pain, a poorly understood aspect of human neuropathic pain, is indicated in
animals by spontaneous foot lifting (SFL). To determine whether SFL is caused by …

Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such
pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here …

A number of rat peripheral neuropathy models have been developed to simulate human
neuropathic pain conditions. The current study sought to determine the relative importance …

We examined the relation between ectopic afferent firing and tactile allodynia in the Chung
model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four …

To characterize various animal models of neuropathic pain, we compared three previously
developed rat models using the same behavioral testing methods. These models involve:(1) …

Physiological and pharmacological evidence both have demonstrated a critical role for
voltage-gated sodium channels (VGSCs) in many types of chronic pain syndromes because …