[HTML][HTML] Peptide shuttles for blood–brain barrier drug delivery

M Sánchez-Navarro, E Giralt - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) limits the delivery of therapeutics to the brain but also
represents the main gate for nutrient entrance. Targeting the natural transport mechanisms …

[HTML][HTML] Biological membrane-penetrating peptides: computational prediction and applications

ECL de Oliveira, KS da Costa, PS Taube… - Frontiers in Cellular …, 2022 - frontiersin.org
Peptides comprise a versatile class of biomolecules that present a unique chemical space
with diverse physicochemical and structural properties. Some classes of peptides are able to …

Accelerating bioactive peptide discovery via mutual information-based meta-learning

W He, Y Jiang, J Jin, Z Li, J Zhao… - Briefings in …, 2022 - academic.oup.com
Recently, machine learning methods have been developed to identify various peptide bio-
activities. However, due to the lack of experimentally validated peptides, machine learning …

Pfeature: A tool for computing wide range of protein features and building prediction models

A Pande, S Patiyal, A Lathwal, C Arora… - Journal of …, 2023 - liebertpub.com
In the last three decades, a wide range of protein features have been discovered to annotate
a protein. Numerous attempts have been made to integrate these features in a software …

[HTML][HTML] Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

[HTML][HTML] Advanced bioinformatics tools in the pharmacokinetic profiles of natural and synthetic compounds with anti-diabetic activity

AM Udrea, G Gradisteanu Pircalabioru, AA Boboc… - Biomolecules, 2021 - mdpi.com
Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …

[HTML][HTML] BBPpredict: a web service for identifying blood-brain barrier penetrating peptides

X Chen, Q Zhang, B Li, C Lu, S Yang, J Long… - Frontiers in …, 2022 - frontiersin.org
Blood-brain barrier (BBB) is a major barrier to drug delivery into the brain in the treatment of
central nervous system (CNS) diseases. Blood-brain barrier penetrating peptides (BBPs), a …

Mesoscopic Model of Extrusion during Solvent‐Free Lithium‐ion Battery Electrode Manufacturing

B Paredes‐Goyes, FM Zanotto… - Batteries & …, 2024 - Wiley Online Library
Solvent‐free (SF) manufacturing of lithium‐ion battery (LIB) electrodes is safer and more
environmentally friendly than the traditional slurry casting approach. However, as a young …

[HTML][HTML] Computational screening for the anticancer potential of seed-derived antioxidant peptides: A cheminformatic approach

TT Chai, JA Koh, CCC Wong, MZ Sabri, FC Wong - Molecules, 2021 - mdpi.com
Some seed-derived antioxidant peptides are known to regulate cellular modulators of ROS
production, including those proposed to be promising targets of anticancer therapy …

[HTML][HTML] Approaches for evaluation of novel CPP-based cargo delivery systems

L Porosk, Ü Langel - Frontiers in Pharmacology, 2022 - frontiersin.org
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …