Application of new measures of nonlinearity to parameter estimation and simulations in individual pharmacokinetic analyses
L Khinkis, M Crotzer - Journal of Pharmacokinetics and …, 2019 - Springer
Since simulation studies are widely used in pharmacokinetics, it is necessary to ascertain
their validity. An important, well-documented, concern that may negatively impact the validity …
their validity. An important, well-documented, concern that may negatively impact the validity …
[PDF][PDF] ON A GLOBAL MEASURE OF NONLINEARITY AND ITS APPLICATION IN PARAMETER ESTIMATION IN NONLINEAR REGRESSION
L KHINKIS - Math. Appl, 2019 - researchgate.net
The theoretical and computational challenges in least squares estimation of parameters in
nonlinear regression models are well documented in statistical literature. The measures of …
nonlinear regression models are well documented in statistical literature. The measures of …