Human ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1,
ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that …

Simple Summary Aldehyde dehydrogenase 1A3 (ALDH1A3) is the primary cause of the high
ALDH activity associated with cancer stem cell (CSC) populations in multiple cancers and its …

Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms
are required for the survival of stem-like tumor cells. We have discovered selective inhibitors …

Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich
conditions favor proliferation and tumor growth, scarcity, and particularly glutamine …

Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many
solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem …

High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and
various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly …

Simple Summary Cancer is found amongst the leading causes of death globally, with its
incidence rates expected to increase even more over the next decades. Human aldehyde …

Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Aims Lactic acidosis (LA) generated in tumor microenvironment promotes tumor metastasis
and drug resistance. This study aimed to demonstrate the impacts and the mechanisms of …

Aldehyde dehydrogenase 1A3 (ALDH1A3) has recently gained attention from researchers in
the cancer field. Several studies have reported ALDH1A3 overexpression in different cancer …