In humans, insulin resistance is a physiological response to infections developed to supply
sufficient energy to the activated immune system. This metabolic adaptation facilitates the …

Apolipoprotein-L1 (APOL1) is a membrane-interacting protein induced by inflammation,
which confers human resistance to infection by African trypanosomes. APOL1 kills …

Abstract Homozygous Apolipoprotein L1 (APOL1) variants G1 and G2 cause APOL1-
mediated kidney disease, purportedly acting as surface cation channels in podocytes …

Chronic kidney disease affects~ 10% of people worldwide and there are no disease
modifying therapeutics that address the underlying cause of any form of kidney disease …

Notwithstanding remaining controversies and uncertainties, promising genomically precise
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …

The risk for metabolic and cardiovascular complications of obesity is defined by body fat
distribution rather than global adiposity. Unlike subcutaneous fat, visceral fat (including …

Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions
involving morphological and motility changes, mitochondrial perturbations, inflammatory …

Since the seminal discovery of the trypanolytic, exonic variants in apolipoprotein L1 (APOL1)
and their association with kidney disease in individuals of recent African ancestry, a wide …

Journal of the American Society of Nephrology Page 1 Journal of the American Society of
Nephrology In Search of the Mechanism of APOL1 Kidney Disease --Manuscript Draft …