[HTML][HTML] Engineering CAR-T cells for next-generation cancer therapy
T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have
shown remarkable success in treating patients with hematologic malignancies and …
shown remarkable success in treating patients with hematologic malignancies and …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Mapping the developing human immune system across organs
Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …
prenatal organs but were limited in describing the developing immune system as a …
Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing
CD3δ SCID is a devastating inborn error of immunity caused by mutations in CD3D,
encoding the invariant CD3δ chain of the CD3/TCR complex necessary for normal …
encoding the invariant CD3δ chain of the CD3/TCR complex necessary for normal …
[HTML][HTML] 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells
Z Wang, HP McWilliams-Koeppen, H Reza, JR Ostberg… - Cell Stem Cell, 2022 - cell.com
Unlimited generation of chimeric antigen receptor (CAR) T cells from human-induced
pluripotent stem cells (iPSCs) is an attractive approach for" off-the-shelf" CAR T cell …
pluripotent stem cells (iPSCs) is an attractive approach for" off-the-shelf" CAR T cell …
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
S Iriguchi, Y Yasui, Y Kawai, S Arima… - Nature …, 2021 - nature.com
Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases …
facilitated further development of T-cell immunotherapy against wide variety of diseases …
[HTML][HTML] EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited resource for
cell therapies, but the derivation of mature cell types remains challenging. The histone …
cell therapies, but the derivation of mature cell types remains challenging. The histone …
Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells
T Ueda, S Shiina, S Iriguchi, S Terakura… - Nature Biomedical …, 2023 - nature.com
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid
tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site …
tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site …
[HTML][HTML] Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
Cell-based immunotherapy has become the new-generation cancer medicine, and" off-the-
shelf" cell products that can be manufactured at large scale and distributed readily to treat …
shelf" cell products that can be manufactured at large scale and distributed readily to treat …