It is well established that cancer is a multi-step process which involves initiation, promotion
and progression. Chemical carcinogens can alter any of these processes to induce their …

The ovarian steroid hormones, estradiol and progesterone, and their nuclear receptors
(estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer …

Background Understanding the molecular control of cell lineages and fate determination in
complex tissues is key to not only understanding the developmental biology and cellular …

Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on
female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but …

Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer
growth, but the mechanisms involved are unknown. Moreover, it remains unclear whether …

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer
death in females worldwide. It is accepted that breast cancer is not a single disease, but …

Background: Compelling evidence shows that progestins regulate breast cancer growth.
Using preclinical models, we demonstrated that antiprogestins are inhibitory when the level …

Major roadblocks to developing effective progesterone receptor (PR)-targeted therapies in
breast cancer include the lack of highly-specific PR modulators, a poor understanding of the …

Background Androgen receptor (AR) signaling and incomplete inhibition of estrogen
signaling may contribute to metastatic breast cancer (MBC) resistance to a nonsteroidal …

A variety of post-translational protein modifications (PTMs) are known to be altered as a
result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast …