The mineralization of type I collagen is a biological process occurring in vertebrates by
which some hard tissues such as bone and dentin are constructed. Due to the extensive …

Purpose of the review Bone's ability to withstand load resisting fracture and adapting to it
highly depends on the quality of its matrix and its regulators. This review focuses on the …

Intrafibrillar mineralization plays a critical role in attaining desired mechanical properties of
bone. It is well known that amorphous calcium phosphate (ACP) infiltrates into the collagen …

Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia characterized by high
fracture rates and broad variations in clinical manifestations ranging from mild to …

Mutations in the COL1A1 and COL1A2 genes, which encode type I collagen, are present in
around 85%–90% of osteogenesis imperfecta (OI) patients. Because type I collagen is the …

At the tissue-scale and above, there are now well-established structure-property
relationships that provide good approximations of the biomechanical performance of bone …

Osteogenesis imperfecta (OI) is a genetic, collagen‐related bone disease that increases the
incidence of bone fractures. Still, the origin of this brittle mechanical behavior remains …

It is well documented that fragility fractures represent an enormous health, economic and
psycho-social burden, leading to severe pain, loss of mobility, and even death. While clinical …

Bioinspired nanocomposites aim to mimic the structure of natural materials. These materials
exhibit excellent mechanical properties such as high strength, toughness, and stiffness …

Functional configuration includes different fields in physical studies in the field of
construction. In many of today's structures, bodies are produced with a one-dimensional …