Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Cardiovascular disease is the leading cause of death worldwide. As such, there is great
interest in identifying novel mechanisms that govern the cardiovascular response to disease …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

Background—Smooth muscle cells (SMCs) are remarkably plastic. Their reversible
differentiation is required for growth and wound healing but also contributes to pathologies …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic
cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke …

Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth
muscle cells) to increased concentrations of growth factors. The mechanisms by which …

Smooth muscle cells (SMCs) contract to perform many physiological functions, including
regulation of blood flow and pressure in arteries, contraction of the pupils, peristalsis of the …