Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being …
SM Rich, FH Leendertz, G Xu… - Proceedings of the …, 2009 - National Acad Sciences
Plasmodium falciparum, the causative agent of malignant malaria, is among the most severe human infectious diseases. The closest known relative of P. falciparum is a chimpanzee …
L Duval, M Fourment, E Nerrienet… - Proceedings of the …, 2010 - National Acad Sciences
We investigated two mitochondrial genes (cytb and cox1), one plastid gene (tufA), and one nuclear gene (ldh) in blood samples from 12 chimpanzees and two gorillas from Cameroon …
Understanding the genetic structure of malaria parasites is essential to predict how fast some phenotypes of interest originate and spread in populations. In the present study, we …
DJ Bacon, C Latour, C Lucas, O Colina… - Antimicrobial agents …, 2007 - Am Soc Microbiol
In vitro drug susceptibility testing with the malaria parasite has been used to assess the antimalarial activities of new compounds and to monitor drug resistance in field isolates. We …
AM McCollum, AC Poe, M Hamel… - The Journal of …, 2006 - academic.oup.com
Background Sulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia …
AM McCollum, K Mueller, L Villegas… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Recent studies indicated that sensitive parasites could increase in frequency in a population when drugs are removed, suggesting that the life span of affordable antimalarial drugs could …
The evolutionary history of Plasmodium vivax has recently been addressed in terms of its origin as a parasite of humans and the age of extant populations. The consensus is that P …
Background Knowledge of the diversity of invasion ligands in malaria parasites in endemic regions is essential to understand how natural selection influences genetic diversity of these …