Why Plasmodium vivax and Plasmodium falciparum are so different? A tale of two clades and their species diversities

AA Escalante, AS Cepeda, MA Pacheco - Malaria Journal, 2022 - Springer
The global malaria burden sometimes obscures that the genus Plasmodium comprises
diverse clades with lineages that independently gave origin to the extant human parasites …

Harnessing genomics and genome biology to understand malaria biology

SK Volkman, DE Neafsey, SF Schaffner… - Nature Reviews …, 2012 - nature.com
Malaria is an important human disease and is the target of a global eradication campaign.
New technological and informatics advancements in population genomics are being …

The origin of malignant malaria

SM Rich, FH Leendertz, G Xu… - Proceedings of the …, 2009 - National Acad Sciences
Plasmodium falciparum, the causative agent of malignant malaria, is among the most severe
human infectious diseases. The closest known relative of P. falciparum is a chimpanzee …

African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus

L Duval, M Fourment, E Nerrienet… - Proceedings of the …, 2010 - National Acad Sciences
We investigated two mitochondrial genes (cytb and cox1), one plastid gene (tufA), and one
nuclear gene (ldh) in blood samples from 12 chimpanzees and two gorillas from Cameroon …

Population Structure and Transmission Dynamics of Plasmodium vivax in Rural Amazonia

MU Ferreira, ND Karunaweera… - The Journal of …, 2007 - academic.oup.com
Understanding the genetic structure of malaria parasites is essential to predict how fast
some phenotypes of interest originate and spread in populations. In the present study, we …

Comparison of a SYBR green I-based assay with a histidine-rich protein II enzyme-linked immunosorbent assay for in vitro antimalarial drug efficacy testing and …

DJ Bacon, C Latour, C Lucas, O Colina… - Antimicrobial agents …, 2007 - Am Soc Microbiol
In vitro drug susceptibility testing with the malaria parasite has been used to assess the
antimalarial activities of new compounds and to monitor drug resistance in field isolates. We …

Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles

AM McCollum, AC Poe, M Hamel… - The Journal of …, 2006 - academic.oup.com
Background Sulfadoxine-pyrimethamine has been widely used as first-line therapy for
uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia …

Common Origin and Fixation of Plasmodium falciparum dhfr and dhps Mutations Associated with Sulfadoxine-Pyrimethamine Resistance in a Low-Transmission …

AM McCollum, K Mueller, L Villegas… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Recent studies indicated that sensitive parasites could increase in frequency in a population
when drugs are removed, suggesting that the life span of affordable antimalarial drugs could …

The origin and age of Plasmodium vivax

OE Cornejo, AA Escalante - Trends in parasitology, 2006 - cell.com
The evolutionary history of Plasmodium vivax has recently been addressed in terms of its
origin as a parasite of humans and the age of extant populations. The consensus is that P …

Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador

A Núñez, FB Ntumngia, Y Guerra, JH Adams, FE Sáenz - Malaria Journal, 2023 - Springer
Background Knowledge of the diversity of invasion ligands in malaria parasites in endemic
regions is essential to understand how natural selection influences genetic diversity of these …