NEDD4 E3 ligase: Functions and mechanism in human cancer
Z Wang, X Hu, M Ye, M Lin, M Chu, X Shen - Seminars in cancer biology, 2020 - Elsevier
A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …
WWP1 E3 ligase at the crossroads of health and disease
The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …
Feedback regulation of ubiquitination and phase separation of HECT E3 ligases
J Li, K Zhu, A Gu, Y Zhang, S Huang… - Proceedings of the …, 2023 - National Acad Sciences
Lipid homeostasis is essential for normal cellular functions and dysregulation of lipid
metabolism is highly correlated with human diseases including neurodegenerative …
metabolism is highly correlated with human diseases including neurodegenerative …
Functions and molecular mechanisms of deltex family ubiquitin E3 ligases in development and disease
L Wang, X Sun, J He, Z Liu - Frontiers in cell and developmental …, 2021 - frontiersin.org
Ubiquitination is a posttranslational modification of proteins that significantly affects protein
stability and function. The specificity of substrate recognition is determined by ubiquitin E3 …
stability and function. The specificity of substrate recognition is determined by ubiquitin E3 …
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
Z Wang, Z Liu, X Chen, J Li, W Yao, S Huang… - Nature …, 2019 - nature.com
HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-
suppressive factors and signaling proteins, and their activities must be tightly regulated to …
suppressive factors and signaling proteins, and their activities must be tightly regulated to …
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that
causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro …
causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro …
Unraveling the potential role of NEDD4-like E3 ligases in cancer
Cancer is a deadly disease worldwide, with an anticipated 19.3 million new cases and 10.0
million deaths occurring in 2020 according to GLOBOCAN 2020. It is well established that …
million deaths occurring in 2020 according to GLOBOCAN 2020. It is well established that …
Notch pathway: a journey from notching phenotypes to cancer immunotherapy
G Monticone, L Miele - Notch Signaling in Embryology and Cancer: Notch …, 2021 - Springer
Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work
of investigators in an uncountable number of biological fields, from development of …
of investigators in an uncountable number of biological fields, from development of …
The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer
R Zhang, W Zhang, Y Zeng, Y Li, J Zhou, Y Zhang… - Cell Death …, 2021 - nature.com
Our previous studies revealed that oncogene CPNE1 is positively correlated with the
occurrence, TNM stage, lymph node metastasis, and distant metastasis of non-small-cell …
occurrence, TNM stage, lymph node metastasis, and distant metastasis of non-small-cell …
Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases
NEDD4-1 E3 ubiquitin protein ligase (NEDD4-1) and WW domain-containing E3 ubiquitin
ligase (WWP2) are HECT family ubiquitin E3 ligases. They catalyze Lys ubiquitination of …
ligase (WWP2) are HECT family ubiquitin E3 ligases. They catalyze Lys ubiquitination of …