High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …

The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

Excessive consumption of added sugars negatively impacts metabolic systems; however,
effects on cognitive function are poorly understood. Also unknown is whether negative …

Traditionally, the leading hypothesis regarding the development of obesity involves caloric
imbalance, whereby the amount of calories consumed exceeds the amount of calories …

Animal models are widely used to develop drugs for treating diabetes mellitus (DM). Insulin
resistance (IR) is one of the main problems in type-2 DM (T2DM). Streptozotocin (STZ) is …

IRS1 and IRS2 are the most important representatives of the IRS protein family and critical
nodes in insulin/IGF1-signaling. Although they are quite similar in their structural and …

In this review, we highlight the specific metabolic effects of fructose consumption that are
involved in the development of metabolic syndrome non-alcoholic fatty liver disease and its …

Objective: In recent years, people have changed their eating habits, and high-fructose-
containing bubble tea has become very popular. High-fructose intake has been suggested …

Major post-cessation metabolic changes include weight gain and hyperglycemia. However,
the association of post-cessation change in fasting serum glucose (FSG) with risk of fatty …

El consumo de fructosa ha aumentado en los últimos 50 años por la incorporación a la dieta
de jarabe de maíz alto en fructosa (JMAF), presente en productos industrializados, como las …