Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Molecular definitions of autophagy and related processes

L Galluzzi, EH Baehrecke, A Ballabio, P Boya… - The EMBO …, 2017 - embopress.org
Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Autosis and autophagic cell death: the dark side of autophagy

Y Liu, B Levine - Cell Death & Differentiation, 2015 - nature.com
It is controversial whether cells truly die via autophagy or whether—in dying cells—
autophagy is merely an innocent bystander or a well-intentioned 'Good Samaritan'trying to …

Development of autophagy inducers in clinical medicine

B Levine, M Packer, P Codogno - The Journal of clinical …, 2015 - Am Soc Clin Investig
Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …

Molecular and biological hallmarks of ageing

JR Aunan, MM Watson, HR Hagland… - Journal of British …, 2016 - academic.oup.com
Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

[HTML][HTML] Prognostic implications of autophagy-associated gene signatures in non-small cell lung cancer

Y Liu, L Wu, H Ao, M Zhao, X Leng, M Liu, J Ma… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Autophagy, a highly conserved cellular proteolysis process, has been involved in non-small
cell lung cancer (NSCLC). We tried to develop a prognostic prediction model for NSCLC …

ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis

SJ Chung, GP Nagaraju, A Nagalingam, N Muniraj… - Autophagy, 2017 - Taylor & Francis
ABSTRACT ADIPOQ/adiponectin, an adipocytokine secreted by adipocytes in the breast
tumor microenvironment, negatively regulates cancer cell growth hence increased levels of …

Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis

P Mistry, MJ Kaplan - Clinical Immunology, 2017 - Elsevier
Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

Targeting autophagy for combating chemoresistance and radioresistance in glioblastoma

MA Taylor, BC Das, SK Ray - Apoptosis, 2018 - Springer
Autophagy is an evolutionarily conserved catabolic process that plays an essential role in
maintaining cellular homeostasis by degrading unneeded cell components. When exposed …

Autophagy in cell life and cell death

AL Anding, EH Baehrecke - Current topics in developmental biology, 2015 - Elsevier
Macroautophagy (hereafter referred to as autophagy) is a process used by the cell to deliver
cytoplasmic components to the lysosome for degradation. Autophagy is most often …