The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Simple Summary Trastuzumab is a humanized antibody that has significantly improved the
management and treatment outcomes of patients with cancers that overexpress HER2 …

Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer
worldwide, with an estimated 2.3 million new cases (11.7%), followed by lung cancer …

Optimal control theory is branch of mathematics that aims to optimize a solution to a
dynamical system. While the concept of using optimal control theory to improve treatment …

Tumor associated angiogenesis is the development of new blood vessels in response to
proteins secreted by tumor cells. These new blood vessels allow tumors to continue to grow …

Simple Summary Tumor heterogeneity influences tumor progression and response to
therapy, introducing a significant challenge in the treatment of breast cancer. We employed …

Human epidermal growth factor receptor 2 positive (HER2+) breast cancer is frequently
treated with drugs that target the HER2 receptor, such as trastuzumab, in combination with …

This study identifies physiological tumor habitats from quantitative magnetic resonance
imaging (MRI) data and evaluates their alterations in response to therapy. Two models of …

The goal of this study is to develop an integrated, mathematical–experimental approach for
understanding the interactions between the immune system and the effects of trastuzumab …

The goal of this study is to experimentally and computationally investigate combination
trastuzumab-paclitaxel therapies and identify potential synergistic effects due to sequencing …