[HTML][HTML] Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Y Song, J Liu, K Zhao, L Gao, J Zhao - Cell metabolism, 2021 - cell.com
High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages

B Wang, H Wang, Y Li, L Song - Lipids in Health and Disease, 2022 - Springer
Recent advances in society have resulted in the emergence of both hyperlipidemia and
obesity as life-threatening conditions in people with implications for various types of …

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression

K Lu, TS Shi, SY Shen, Y Shi, HL Gao, J Wu, X Lu… - Cell metabolism, 2022 - cell.com
Hepatic osteodystrophy (HOD) is a metabolic bone disease that is often associated with
chronic liver disease and is marked by bone loss. Here, we demonstrate that hepatic …

Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women

I Zolfaroli, E Ortiz, MÁ García-Pérez, JJ Hidalgo-Mora… - Maturitas, 2021 - Elsevier
Objective Experimental studies suggest that lipids affect bone metabolism. We aimed to
elucidate whether lipid levels are associated with bone mineral density (BMD) in a cohort of …

Modulation of bone and marrow niche by cholesterol

W Yin, Z Li, W Zhang - Nutrients, 2019 - mdpi.com
Bone is a complex tissue composing of mineralized bone, bone cells, hematopoietic cells,
marrow adipocytes, and supportive stromal cells. The homeostasis of bone and marrow …

[HTML][HTML] Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through …

L Zhang, Y Yang, Z Liao, Q Liu, X Lei, M Li, Z Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Wear particle-induced periprosthetic osteolysis (PPO) is a common long-term
complication of total joint arthroplasty, and represents the major cause of aseptic loosening …

New function of cholesterol oxidation products involved in osteoporosis pathogenesis

Y Che, J Yang, F Tang, Z Wei, Y Chao, N Li… - International Journal of …, 2022 - mdpi.com
Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength,
microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is …

Influence of cholesterol on the regulation of osteoblast function

A Akhmetshina, D Kratky, E Rendina-Ruedy - Metabolites, 2023 - mdpi.com
Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion.
Osteoblasts are responsible for proper bone formation and remodeling, and function. These …

Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics

C Bao, T Wu, S Zhu, X Wang, Y Zhang, X Wang… - Clinical …, 2023 - portlandpress.com
Osteoporosis is a metabolic bone disease that affects hundreds of millions of people
worldwide and is characterized by excessive loss of bone protein and mineral content. The …

[HTML][HTML] The regulatory roles of miR-26a in the development of fracture and osteoblasts

J Zou, J Sun, H Chen, X Fan, Z Qiu, Y Li… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background MicroRNAs (miRNAs) play a vital role in the bone development and bone
regeneration. In this study, we investigated the effects of miR-26a in osteoblasts and …