Cortical interneurons in autism
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …
do individuals with autism share an overlapping set of atypical behaviors and symptoms …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear
how convergent biological processes in affected individuals may give rise to symptoms …
how convergent biological processes in affected individuals may give rise to symptoms …
Differences in regional brain structure in toddlers with autism are related to future language outcomes
Abstract Language and social symptoms improve with age in some autistic toddlers, but not
in others, and such outcome differences are not clearly predictable from clinical scores …
in others, and such outcome differences are not clearly predictable from clinical scores …
[PDF][PDF] Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
Single-cell genomics and regulatory networks for 388 human brains
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the
brain. Yet little is understood about how genetic variants influence cell-level gene …
brain. Yet little is understood about how genetic variants influence cell-level gene …
Microglial contribution to the pathology of neurodevelopmental disorders in humans
R Matuleviciute, ET Akinluyi, TAO Muntslag… - Acta …, 2023 - Springer
Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …
Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms
Background Social affective and communication symptoms are central to autism spectrum
disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display …
disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display …
[HTML][HTML] Batch correction and harmonization of–Omics datasets with a tunable median polish of ratio
Large scale− omics datasets can provide new insights into normal and disease-related
biology when analyzed through a systems biology framework. However, technical artefacts …
biology when analyzed through a systems biology framework. However, technical artefacts …
Epigenetic alterations of brain non-neuronal cells in major mental diseases
HM Abdolmaleky, M Martin, JR Zhou, S Thiagalingam - Genes, 2023 - mdpi.com
The tissue-specific expression and epigenetic dysregulation of many genes in cells derived
from the postmortem brains of patients have been reported to provide a fundamental …
from the postmortem brains of patients have been reported to provide a fundamental …