Amino acids form peptides and proteins and are therefore considered the main building
blocks of life. The kidney has an important but under-appreciated role in the synthesis …

Autosomal dominant polycystic kidney disease (ADPKD) is a chronic systemic disease that
affects all races and ethnicities. It is the fourth leading cause of end-stage kidney disease …

Ketogenic metabolic therapy (KMT) is a medical nutrition therapy to address certain health
and disease conditions. It is increasingly used for many non-communicable diseases that …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease
characterized by the formation of fluid-filled renal cysts, loss of mitochondrial function …

Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the
population worldwide, accounting for more than 843 million (M) individuals. The prevalence …

Background Very-low-carbohydrate diets, including ketogenic and carnivore diets, are
gaining popularity for the experimental treatment of a wide range of disorders, including …

Our research has shown that interventions producing a state of ketosis are highly effective in
rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially …

Ketogenic diets have been widely used for weight loss and are increasingly used in the
management of type 2 diabetes. Despite evidence that ketones have multiple positive effects …

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Background: Recent findings have highlighted that abnormal energy metabolism is a key
feature of autosomal-dominant polycystic kidney disease (ADPKD). Emerging evidence …