Dry eye (DE) disease, which is primarily linked to aqueous deficiency, is an escalating
health issue worldwide, mainly due to the widespread use of electronic devices. The major …

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water
channels, facilitates osmotically driven water flux across biological membranes and the …

As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the
normal physiological functions of ocular tissues. This review provides an overview of the …

Dry eye disease (DED) which affects millions of people worldwide is an ocular surface
disease that is strongly associated with pain, discomfort, and visual disturbances. Altered …

Dry eye disease (DED) is caused by a reduction in the volume or quality of tears. The
prevalence of DED is estimated to be 100 million in the developed world. As aging is a risk …

Aging is the most important known risk factor for dry eye is aging, which is associated with
changes in the structure and function of the lacrimal gland (LG) and characterized by …

The altered activity generated by corneal neuronal injury can result in morphological and
physiological changes in the architecture of synaptic connections in the nervous system …

The cornea is an avascular, transparent tissue that allows light to enter the visual system.
Accurate vision requires proper maintenance of the cornea's integrity and structure. Due to …

Sjogren's syndrome (SS) is a chronic autoimmune disease. Mainly due to the infiltration of
lymphoplasmic cells into the exocrine glands, especially the salivary glands and lacrimal …

Gabapentin (GBP) was originally developed as a potential agonist for Gamma-Amino-
Butyric-Acid (GABA) receptors, aiming to inhibit the activation of pain-signaling neurons …