Droplet-based method and apparatus for composite single-cell nucleic acid analysis

A Regev, EZ Macosko, SA McCarroll… - US Patent …, 2023 - Google Patents
US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …

Multiplex analysis of single cell constituents

J Gaublomme, A Regev - US Patent 11,092,607, 2021 - Google Patents
The present invention relates to methods for high multiplex protein or cellular constituent
analysis in single cells or single isolated aggregations of cellular constituents. The methods …

High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

PC Blainey, MW Seely, R Stocker, K Zengler… - US Patent …, 2019 - Google Patents
(57) ABSTRACT A method of screening for at least one biological entity of interest using a
microfabricated device which has a top surface defining an array of microwells. A sample is …

Systems and methods for epigenetic sequencing

A Rotem, O Ram, BE Bernstein, DA Weitz - US Patent 11,001,883, 2021 - Google Patents
The present invention generally relates to microfluidics and/or epigenetic sequencing. In
one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed …

Single-cell proteomic assay using aptamers

J Gaublomme, A Regev - US Patent 11,072,816, 2021 - Google Patents
The application relates to proteome analysis in single cells. Specifically, disclosed are high
throughput methods of detecting proteins in single cells using barcoding, aptamers and …

Systems and methods for barcoding nucleic acids

DA Weitz, AM Klein, I Akartuna, L Mazutis… - US Patent …, 2020 - Google Patents
2019-01-11 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE, VILNIUS
UNIVERSITY reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE …

Systems and methods for barcoding nucleic acids

DA Weitz, AM Klein, I Akartuna, L Mazutis… - US Patent …, 2021 - Google Patents
2019-01-11 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Semi-permeable arrays for analyzing biological systems and methods of using same

TM Gierahn, JC Love, TK Hughes… - US Patent …, 2024 - Google Patents
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate
hydrogen phosphate dichloride Chemical compound P (= O)(O)(O)[O-].[K+]. P (= O)(O)([O …

High-throughput dynamic reagent delivery system

B Anindita, A Regev, DA Weitz, A Rotem… - US Patent …, 2024 - Google Patents
US11904310B2 - High-throughput dynamic reagent delivery system - Google Patents
US11904310B2 - High-throughput dynamic reagent delivery system - Google Patents High-throughput …

System and methods for massively parallel analysis of nucleic acids in single cells

DS Johnson, EH Meyer - US Patent 10,106,789, 2018 - Google Patents
Methods and systems are provided for massively parallel genetic analysis of single cells in
emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell …