The essential medicinal chemistry of curcumin: miniperspective

KM Nelson, JL Dahlin, J Bisson, J Graham… - Journal of medicinal …, 2017 - ACS Publications
Curcumin is a constituent (up to∼ 5%) of the traditional medicine known as turmeric. Interest
in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led …

Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19

H Xu, S Li, J Liu, J Cheng, L Kang… - Proceedings of the …, 2023 - National Acad Sciences
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health concern,
and effective antiviral reagents are urgently needed. Traditional Chinese medicine theory …

Chemistry: Chemical con artists foil drug discovery

J Baell, MA Walters - Nature, 2014 - nature.com
Chemistry: Chemical con artists foil drug discovery | Nature Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

CG Begley, M Ashton, J Baell, M Bettess… - Science Translational …, 2021 - science.org
Drug repurposing is promoted as a cost-and time-effective mechanism for providing new
medicines. Often, however, there is insufficient consideration by academic researchers of …

Feeling nature's PAINS: natural products, natural product drugs, and pan assay interference compounds (PAINS)

JB Baell - Journal of natural products, 2016 - ACS Publications
We have previously reported on classes of compounds that can interfere with bioassays via
a number of different mechanisms and termed such compounds Pan Assay INterference …

Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies

J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Antiviral potential of curcumin

D Mathew, WL Hsu - Journal of functional foods, 2018 - Elsevier
The use of synthetic drugs has increased over the recent years, but plant-based drugs are
more suitable in terms of least side effects. Since ancient times mankind has been …

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

M Kibble, N Saarinen, J Tang, K Wennerberg… - Natural product …, 2015 - pubs.rsc.org
Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems-
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …

The essential medicinal chemistry of cannabidiol (CBD)

KM Nelson, J Bisson, G Singh, JG Graham… - Journal of medicinal …, 2020 - ACS Publications
This Perspective of the published essential medicinal chemistry of cannabidiol (CBD)
provides evidence that the popularization of CBD-fortified or CBD-labeled health products …