AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques
A Dashti, S Sukkestad, AM Horner, M Neja, Z Siddiqi… - Nature Medicine, 2023 - nature.com
The main barrier to HIV cure is a persistent reservoir of latently infected CD4+ T cells
harboring replication-competent provirus that fuels rebound viremia upon antiretroviral …
harboring replication-competent provirus that fuels rebound viremia upon antiretroviral …
Latency reversal 2.0: giving the immune system a seat at the table
Abstract Purpose of Review For most people living with HIV (PLWH), treatment with effective
antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of …
antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of …
Interests of the non-human primate models for HIV cure research
G Terrade, N Huot, C Petitdemange, M Lazzerini… - Vaccines, 2021 - mdpi.com
Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …
CD8+ lymphocytes do not impact SIV reservoir establishment under ART
Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected
individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While …
individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While …
Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques
VEK Walker-Sperling, NB Mercado… - Nature …, 2022 - nature.com
The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies
have shown that therapeutic vaccination or broadly neutralizing antibody (bNAb) …
have shown that therapeutic vaccination or broadly neutralizing antibody (bNAb) …
β-catenin regulates HIV latency and modulates HIV reactivation
HJ Barbian, MS Seaton, SD Narasipura… - PLoS …, 2022 - journals.plos.org
Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit
or prevent viral reactivation. While these strategies have shown promise, they have only …
or prevent viral reactivation. While these strategies have shown promise, they have only …
Advances in pediatric HIV-1 cure therapies and reservoir assays
P Khetan, Y Liu, A Dhummakupt, D Persaud - Viruses, 2022 - mdpi.com
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment
(ART)-free remission and cure for persons living with HIV-1 are being made with the advent …
(ART)-free remission and cure for persons living with HIV-1 are being made with the advent …
New latency reversing agents for HIV-1 cure: insights from nonhuman primate models
Antiretroviral therapy (ART) controls human immunodeficiency virus 1 (HIV-1) replication
and prevents disease progression but does not eradicate HIV-1. The persistence of a …
and prevents disease progression but does not eradicate HIV-1. The persistence of a …
Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo
J Jansen, S Kroeze, S Man, M Andreini… - Microbiology …, 2024 - Am Soc Microbiol
Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-
1) reservoir using a combination of compounds with different mechanisms of action are …
1) reservoir using a combination of compounds with different mechanisms of action are …
So Pathogenic or So What?—A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research
AJ Kleinman, I Pandrea, C Apetrei - Viruses, 2022 - mdpi.com
HIV infection requires lifelong antiretroviral therapy (ART) to control disease progression.
Although ART has greatly extended the life expectancy of persons living with HIV (PWH) …
Although ART has greatly extended the life expectancy of persons living with HIV (PWH) …