Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease

NR Jabir, FR Khan, S Tabrez - CNS neuroscience & …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder
characterized by excessive deposition of β‐amyloid (Aβ) oligomers, and neurofibrillary …

Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review

Y Jiang, H Gao, G Turdu - Bioorganic chemistry, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million
people worldwide, and cholinergic hypothesis is considered as an important hypotheses in …

Characterization of phenolic profile by LC‐ESI‐MS/MS and enzyme inhibitory activities of two wild edible garlic: Allium nigrum L. and Allium subhirsutum L.

A Emir, C Emir, H Yıldırım - Journal of food biochemistry, 2020 - Wiley Online Library
In our study, Allium nigrum L. and Allium subhirsutum L. were investigated in terms of
phenolic profile, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and …

Nanodisc-associated acetylcholinesterase as a novel model system of physiological relevant membrane-bound cholinesterases. Inhibition by phenolic compounds

PB Salazar, FG Dupuy, MC Fiori, SM Stanfield… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Acetylcholinesterase (AChE) plays a pivotal role in the cholinergic system, and its inhibition
is sought after in a wide range of applications, from insect control to Alzheimer's disease …

Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin‐induced peroxidase activity

R Lagoa, AK Samhan‐Arias, C Gutierrez‐Merino - Biofactors, 2017 - Wiley Online Library
There are large differences between flavonoids to protect against apoptosis, a process in
which cytochrome c (Cyt c) plays a key role. In this work, we show that 7 of 13 flavonoids …

A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination

PB Salazar, M Fanzone, BA Zabala… - … Science and Pollution …, 2023 - Springer
Vineyard-derived pomace is a byproduct of the wine industry that can have a negative
impact on the environment if it is only disposed of or used as a fertilizer. Owing to its …

Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors

S Schwarthoff, N Tischer, H Sager, B Schaetz… - Bioorganic & Medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. It is associated with the
impairment of memory and other cognitive functions that are mainly caused by progressive …

Interaction of catechins with Human erythrocytes

K Naparlo, G Bartosz, I Stefaniuk, B Cieniek… - Molecules, 2020 - mdpi.com
The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin,(−)-
epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes …

Improvement of Key Molecular Events Linked to Alzheimer's Disease Pathology Using Postbiotics

GA Bulacios, PG Cataldo, JR Naja, EP de Chaves… - ACS …, 2023 - ACS Publications
In the past 50 years, life expectancy has increased by more than 20 years. One
consequence of this increase in longevity is the rise of age-related diseases such as …

[HTML][HTML] Membrane order and ionic strength modulation of the inhibition of the membrane-bound acetylcholinesterase by epigallocatechin‑3‑gallate

PB Salazar, FG Dupuy, AAM Collado… - Biochimica et Biophysica …, 2019 - Elsevier
In the present work, we analyzed how external factors can modulate the efficiency of
epigallocatechin‑3‑O‑gallate (EGCG) inhibition of a membrane-bound isoform of the …