Acute pancreatitis: diagnosis and treatment

P Szatmary, T Grammatikopoulos, W Cai, W Huang… - Drugs, 2022 - Springer
Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

Targeting fibrosis: The bridge that connects pancreatitis and pancreatic cancer

C Huang, J Iovanna, P Santofimia-Castaño - International Journal of …, 2021 - mdpi.com
Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …

Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality

K Ocskay, Z Vinkó, D Németh, L Szabó, J Bajor… - Scientific reports, 2021 - nature.com
The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases
still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and …

Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international …

A Nagy, MF Juhász, A Görbe, A Váradi, F Izbéki… - Pancreatology, 2021 - Elsevier
Background Metabolic risk factors, such as obesity, hypertension, and hyperlipidemia are
independent risk factors for the development of various complications in acute pancreatitis …

COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways

Y Wang, HT Li, G Liu, CS Jiang, YH Ni, JH Zeng, X Lin… - Cellular …, 2024 - Elsevier
Background Pancreatic fibrosis is one of the most important pathological features of chronic
pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an …

Distinct serum immune profiles define the spectrum of acute and chronic pancreatitis from the multicenter prospective evaluation of chronic pancreatitis for …

B Lee, EK Jones, M Manohar, L Li, D Yadav… - Gastroenterology, 2023 - Elsevier
Background & Aims Pancreatitis is a disease continuum, starting with acute pancreatitis (AP)
and progressing in some cases to recurrent acute pancreatitis (RAP) and chronic …

In-hospital patient education markedly reduces alcohol consumption after alcohol-induced acute pancreatitis

R Nagy, K Ocskay, A Váradi, M Papp, Z Vitális, F Izbéki… - Nutrients, 2022 - mdpi.com
Although excessive alcohol consumption is by far the most frequent cause of recurrent acute
pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence …

Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage

A Szentesi, N Farkas, Z Sipos, P Mátrai, Á Vincze… - Gut, 2022 - gut.bmj.com
Chronic pancreatitis (CP) is characterised by irreversible damage to the pancreas causing
endocrine and exocrine dysfunction which results in decreased quality of life and reduced …

Impact of alcohol and smoking cessation on the course of chronic pancreatitis

P Göltl, K Murillo, O Simsek, M Wekerle, MP Ebert… - Alcohol, 2024 - Elsevier
Objectives Alcohol and nicotine are the two most important risk factors of chronic
pancreatitis, and they often occur together. It is still unclear how much they influence the …

Restoring CFTR function with Orkambi decreases the severity of alcohol‐induced acute pancreatitis

V Venglovecz, A Grassalkovich, E Tóth… - The Journal of …, 2024 - Wiley Online Library
Heavy alcohol intake is one of the most common causes of acute pancreatitis (AP). We have
previously shown that ethanol (EtOH) decreases the expression and activity of the cystic …