Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Alzheimer's disease (AD) is a multifactorial disease with a heterogeneous etiology. The
pathology of Alzheimer's disease is characterized by amyloid-beta and …

Abstract Background Choroid plexuses (ChPs) are intraventricular structures mainly
composed by specialized epithelial cells interconnected by tight junctions that establish the …

Abstract Machine learning can be used to create “biologic clocks” that predict age. However,
organs, tissues, and biofluids may age at different rates from the organism as a whole. We …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a conserved neuropeptide,
which confers diverse anti-aging endocrine and paracrine/autocrine effects, including anti …

The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in
aging and Alzheimer's disease (AD) shows extensive proteomic alterations including …

Choroid plexus (ChP) epithelium is composed of specialized multiciliated cells. By using
multiple microscopic techniques, biochemical approaches in various mutant mice and …

Powassan viruses (POWV) are emergent tick-borne flaviviruses that cause severe
neurologic disease in humans. Subcutaneous inoculation of C57BL/6 mice with POWV …

The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in
aging and Alzheimer's disease (AD) shows extensive proteomic alterations including …