[HTML][HTML] Computational methods for protein localization prediction

Y Jiang, D Wang, W Wang, D Xu - Computational and Structural …, 2021 - Elsevier
The accurate annotation of protein localization is crucial in understanding protein function in
tandem with a broad range of applications such as pathological analysis and drug design …

Recent advancements in subcellular proteomics: growing impact of organellar protein niches on the understanding of cell biology

V Bhushan, A Nita-Lazar - Journal of Proteome Research, 2024 - ACS Publications
The mammalian cell is a complex entity, with membrane-bound and membrane-less
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …

Prediction of antitubercular peptides from sequence information using ensemble classifier and hybrid features

SS Usmani, S Bhalla, GPS Raghava - Frontiers in pharmacology, 2018 - frontiersin.org
Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of
drug resistant strains. Antitubercular peptides may provide an alternate approach to combat …

Prediction of high anti-angiogenic activity peptides in silico using a generalized linear model and feature selection

JL Blanco, AB Porto-Pazos, A Pazos… - Scientific reports, 2018 - nature.com
Screening and in silico modeling are critical activities for the reduction of experimental costs.
They also speed up research notably and strengthen the theoretical framework, thus …

Detection of transcription factors binding to methylated DNA by deep recurrent neural network

H Li, Y Gong, Y Liu, H Lin, G Wang - Briefings in bioinformatics, 2022 - academic.oup.com
Transcription factors (TFs) are proteins specifically involved in gene expression regulation. It
is generally accepted in epigenetics that methylated nucleotides could prevent the TFs from …

Characterization and Comparison Analysis of Milk Fat Globule Membrane Proteins between Human and Porcine Milk

H Zhao, X Liu, X Amantai, J Bi, X Cao… - Journal of Agricultural …, 2024 - ACS Publications
This study aimed to explore the differences in milk fat globule membrane (MFGM) proteins
between human milk (HM) and porcine milk (PM) using a label-free quantitative proteomic …

Predicting preference of transcription factors for methylated DNA using sequence information

ML Liu, W Su, JS Wang, YH Yang, H Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Transcription factors play key roles in cell-fate decisions by regulating 3D genome
conformation and gene expression. The traditional view is that methylation of DNA hinders …

Ensemble of multiple classifiers for multilabel classification of plant protein subcellular localization

W Wattanapornprom, C Thammarongtham… - Life, 2021 - mdpi.com
The accurate prediction of protein localization is a critical step in any functional genome
annotation process. This paper proposes an improved strategy for protein subcellular …

Bird eye view of protein subcellular localization prediction

R Kumar, SK Dhanda - Life, 2020 - mdpi.com
Proteins are made up of long chain of amino acids that perform a variety of functions in
different organisms. The activity of the proteins is determined by the nucleotide sequence of …

[HTML][HTML] Diagnostic value of plasma microRNAs for lung cancer using support vector machine model

W Wang, M Ding, X Duan, X Feng, P Wang… - Journal of …, 2019 - ncbi.nlm.nih.gov
Aim: Small single-stranded non-coding RNAs (miRNAs) play an important role in
carcinogenesis through degrading target mRNAs. However, the diagnostic value of miRNAs …