Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and
bone marrow failure syndrome which responds to immunosuppressive therapies. We show …

Summary VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a
pleiotropic, severe autoinflammatory disease caused by somatic mutations in the ubiquitin …

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an
important determinant of adaptive immunity. We estimated the abundance of TCR …

The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and
non-infectious diseases. We describe a protocol for amplifying, sequencing, and analyzing …

Zipf's law, which states that the probability of an observation is inversely proportional to its
rank, has been observed in many domains. While there are models that explain Zipf's law in …

Immune repertoires rely on diversity of T-cell receptors and immunoglobulins to protect us
against foreign threats. The ability to recognize a wide variety of pathogens is linked to the …

In this paper we discuss the applicability of numerical descriptors and statistical physics
concepts to characterize complex biological systems observed at microscopic level through …

The adaptive immune system is a dynamical, self-organized multiscale system that protects
vertebrates from both pathogens and internal irregularities, such as tumors. For these …