GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Summary Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and
hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) …

Fluorescent Ca2+ reporters are widely used as readouts of neuronal activities. Here we
designed R-CaMP2, a high-affinity red genetically encoded calcium indicator (GECI) with a …

Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …

Homeostatic processes have been proposed to explain the discrepancy between the
dynamics of synaptic plasticity and the stability of brain function. Forms of synaptic plasticity …

Epilepsy is a frequent neurological disorder, although onset and progression of seizures
remain difficult to predict in affected patients, irrespective of their epileptogenic condition …

Identifying the neuronal ensembles that respond to specific stimuli and mapping their
projection patterns in living animals are fundamental challenges in neuroscience. To this …

Proper brain wiring during development is pivotal for adult brain function. Neurons display a
high degree of polarization both morphologically and functionally, and this polarization …

Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake,
and therefore have instructive roles in synaptic function and neuronal response properties …