Pyrimidine (imatinib, dasatinib, nilotinib and pazopanib), pyridine (sorafenib) and pyrrole
(sunitinib) tyrosine kinase inhibitors (TKIs) are multi-targeted TKIs with high activity towards …

LC–MS/MS is an increasingly important tool in therapeutic drug monitoring as it offers
increased sensitivity and specificity compared to other methods, and may be the only viable …

BACKGROUND: Tyrosine Kinase Inhibitors (TKIs) are a class of targeted drugs for the
treatment of malignant pathologies. The metabolic profile of these drugs can result in great …

Clinical laboratory medicine has seen the introduction and evolution of liquid
chromatography tandem mass spectrometry in routine clinical laboratories over the last 10 …

To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate
method for simultaneous determination of anticancer tyrosine kinase inhibitors (TKIs) …

The therapeutic activity of drugs can be optimized by establishing an individualized dosage,
based on the measurement of the drug concentration in the serum, particularly if the drugs …

In the present work, the electrochemical oxidation of a new generation of anticancer drug,
imatinib (Ima), using differential pulse voltammetry (DPV) on anodically pretreated boron …

BACKGROUND: Increasing numbers of tyrosine kinase inhibitors (TKIs) were studied and
approved for therapy of malignancies and other diseases. The aim of this study was to …

A sensitive, sophisticated and practical bioanalytical assay for the simultaneous
determination of six tyrosine kinase inhibitors (imatinib, sunitinib, nilotinib, dasatinib …

The number of patients suffering from cancer is constantly increasing and, consequently, the
number of different chemotherapy treatments administered is increasing. Given the high …