Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Autophagosome formation and maturation involve the two ubiquitin-like systems: The ATG8
and ATG12 systems. ATG8 (LC3s and gamma-aminobutyric acid receptor–associated …

INTRODUCTION Macroautophagy (hereafter autophagy) is an evolutionarily conserved
lysosomal degradation pathway. It ensures cellular homeostasis and health by removing …

Selective autophagy recycles damaged organelles and clears intracellular pathogens to
prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during …

Plants have evolved sophisticated mechanisms to recycle intracellular constituents, which
are essential for developmental and metabolic transitions; for efficient nutrient reuse; and for …

Members of the Atg8 family of proteins are conjugated to autophagosomal membranes,
where they have been proposed to drive autophagosome formation and selective …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …