Readers of histone methylarginine marks
S Gayatri, MT Bedford - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation …
0.5% of all arginine residues in the cells. There are three types of arginine methylation …
Targeting epigenetic regulations in cancer
Epigenetic regulation of gene expression is a dynamic and reversible process with DNA
methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking …
methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking …
Identification of a candidate gene panel for the early diagnosis of prostate cancer
GHJM Leyten, D Hessels, FP Smit, SA Jannink… - Clinical cancer …, 2015 - AACR
Abstract Purpose: Serum PSA (sPSA) testing has led to the identification of patients with
indolent prostate cancer, and inevitably overtreatment has become a concern. Progensa …
indolent prostate cancer, and inevitably overtreatment has become a concern. Progensa …
Development and classes of epigenetic drugs for cancer
D Dhanak, P Jackson - Biochemical and biophysical research …, 2014 - Elsevier
Emerging evidence supports an important, etiologic role for epigenetic modifications in
cancer. Various post translational modifications of histone proteins together with DNA …
cancer. Various post translational modifications of histone proteins together with DNA …
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
Abstract Distal-less homeobox-1 (DLX1) is a well-established non-invasive biomarker for
prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease …
prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease …
The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery
Prostate cancer is the most commonly diagnosed noncutaneous cancer in American men.
TDRD1, a germ cell-specific gene, is erroneously expressed in more than half of prostate …
TDRD1, a germ cell-specific gene, is erroneously expressed in more than half of prostate …
Validation of novel biomarkers for prostate cancer progression by the combination of bioinformatics, clinical and functional studies
S Alinezhad, RM Väänänen, J Mattsson, Y Li… - PloS one, 2016 - journals.plos.org
The identification and validation of biomarkers for clinical applications remains an important
issue for improving diagnostics and therapy in many diseases, including prostate cancer …
issue for improving diagnostics and therapy in many diseases, including prostate cancer …
Structure and function of eTudor domain containing TDRD proteins
B Gan, S Chen, H Liu, J Min, K Liu - Critical Reviews in …, 2019 - Taylor & Francis
Tudor domain-containing (TDRD) proteins, as a family of evolutionarily conserved proteins,
have been studied extensively in recent years in terms of their biological and biochemical …
have been studied extensively in recent years in terms of their biological and biochemical …
Mind the methyl: methyllysine binding proteins in epigenetic regulation
Epigenetics is defined as the phenomenon of heritable phenotypic traits that are not
governed by alteration of the genetic code. Major epigenetic control mechanisms include …
governed by alteration of the genetic code. Major epigenetic control mechanisms include …
Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer
Purpose To explore differential methylation of HAAO, HOXD3, LGALS3, PITX2, RASSF1 and
TDRD1 as a molecular tool to predict biochemical recurrence (BCR) in patients with high …
TDRD1 as a molecular tool to predict biochemical recurrence (BCR) in patients with high …