Analysing biological pathways in genome-wide association studies

K Wang, M Li, H Hakonarson - Nature Reviews Genetics, 2010 - nature.com
Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans

FR Sharp, GC Jickling, B Stamova… - Journal of Cerebral …, 2011 - journals.sagepub.com
Whole genome expression microarrays can be used to study gene expression in blood,
which comes in part from leukocytes, immature platelets, and red blood cells. Since these …

Biological pathway analysis by ArrayUnlock and ingenuity pathway analysis

Á Jiménez-Marín, M Collado-Romero, M Ramirez-Boo… - BMC proceedings, 2009 - Springer
Background Once a list of differentially expressed genes has been identified from a
microarray experiment, a subsequent post-analysis task is required in order to find the main …

FungiFun: a web-based application for functional categorization of fungal genes and proteins

S Priebe, J Linde, D Albrecht, R Guthke… - Fungal Genetics and …, 2011 - Elsevier
FungiFun assigns functional annotations to fungal genes or proteins and performs gene set
enrichment analysis. Based on three different classification methods (FunCat, GO and …

Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways

EM Wexler, E Rosen, D Lu, GE Osborn, E Martin… - Science …, 2011 - science.org
Wnt proteins are critical to mammalian brain development and function. The canonical Wnt
signaling pathway involves the stabilization and nuclear translocation of β-catenin; however …

STAR NET 2: a web-based tool for accelerating discovery of gene regulatory networks using microarray co-expression data

D Jupiter, H Chen, V VanBuren - BMC bioinformatics, 2009 - Springer
Background Although expression microarrays have become a standard tool used by
biologists, analysis of data produced by microarray experiments may still present …

Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription …

LA Cogburn, N Trakooljul, X Wang, LE Ellestad… - BMC genomics, 2020 - Springer
Background The fasting-refeeding perturbation has been used extensively to reveal specific
genes and metabolic pathways that control energy metabolism in the chicken. Most global …

The structure of a gene co-expression network reveals biological functions underlying eQTLs

N Villa-Vialaneix, L Liaubet, T Laurent, P Cherel… - PloS one, 2013 - journals.plos.org
What are the commonalities between genes, whose expression level is partially controlled
by eQTL, especially with regard to biological functions? Moreover, how are these genes …

Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing

JJ Connolly, H Hakonarson - BioMed Research International, 2012 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder, known to have a
strong genetic component. Concordance between monozygotic twins is approximately 30 …

Pathway results from the chicken data set using GOTM, Pathway Studio and Ingenuity softwares

A Bonnet, S Lagarrigue, L Liaubet, C Robert-Granié… - BMC proceedings, 2009 - Springer
Background As presented in the introduction paper, three sets of differentially regulated
genes were found after the analysis of the chicken infection data set from EADGENE …