Concepts and functions of small RNA pathways in C. elegans
RF Ketting, L Cochella - Current topics in developmental biology, 2021 - Elsevier
A diversity of gene regulatory mechanisms drives the changes in gene expression required
for animal development. Here, we discuss the developmental roles of a class of gene …
for animal development. Here, we discuss the developmental roles of a class of gene …
Small RNAs in parasitic nematodes–forms and functions
Small RNAs are important regulators of gene expression. They were first identified in
Caenorhabditis elegans, but it is now apparent that the main small RNA silencing pathways …
Caenorhabditis elegans, but it is now apparent that the main small RNA silencing pathways …
Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors
Piwi‐interacting RNAs (piRNAs) play key roles in germline development and genome
defence in metazoans. In C. elegans, piRNAs are transcribed from> 15,000 discrete …
defence in metazoans. In C. elegans, piRNAs are transcribed from> 15,000 discrete …
Single-worm long-read sequencing reveals genome diversity in free-living nematodes
Obtaining sufficient genetic material from a limited biological source is currently the primary
operational bottleneck in studies investigating biodiversity and genome evolution. In this …
operational bottleneck in studies investigating biodiversity and genome evolution. In this …
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis
M Mazzetto, LE Gonzalez, N Sanchez… - Genome …, 2024 - genome.cshlp.org
Chromatin organization in the C. elegans germline is tightly regulated and critical for germ
cell differentiation. Although certain germline epigenetic regulatory mechanisms have been …
cell differentiation. Although certain germline epigenetic regulatory mechanisms have been …
Fluctuations in chromatin state at regulatory loci occur spontaneously under relaxed selection and are associated with epigenetically inherited variation in C. elegans …
R Wilson, M Le Bourgeois, M Perez, P Sarkies - PLoS Genetics, 2023 - journals.plos.org
Some epigenetic information can be transmitted between generations without changes in
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …
Analysis of repeat elements in the Pristionchus pacificus genome reveals an ancient invasion by horizontally transferred transposons
M Athanasouli, C Rödelsperger - BMC genomics, 2022 - Springer
Background Repetitive sequences and mobile elements make up considerable fractions of
individual genomes. While transposition events can be detrimental for organismal fitness …
individual genomes. While transposition events can be detrimental for organismal fitness …
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability
RJC Rodrigues, AM de Jesus Domingues… - Genes & …, 2019 - genesdev.cshlp.org
Piwi proteins are important for germ cell development in most animals. These proteins are
guided to specific targets by small guide RNAs, referred to as piRNAs or 21U RNAs in …
guided to specific targets by small guide RNAs, referred to as piRNAs or 21U RNAs in …
The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription
AC Berkyurek, G Furlan, L Lampersberger… - The EMBO …, 2021 - embopress.org
PIWI‐interacting RNAs (piRNAs) are genome‐encoded small RNAs that regulate germ cell
development and maintain germline integrity in many animals. Mature piRNAs engage Piwi …
development and maintain germline integrity in many animals. Mature piRNAs engage Piwi …
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans
C Perez-Borrajero, N Podvalnaya… - Genes & …, 2021 - genesdev.cshlp.org
Piwi-interacting RNAs (piRNAs) constitute a class of small RNAs that bind PIWI proteins and
are essential to repress transposable elements in the animal germline, thereby promoting …
are essential to repress transposable elements in the animal germline, thereby promoting …