The prevention and management of malaria is primarily based on the use of drugs. Clinical
trials have however revealed that between individuals there is large variability in the …

Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Owing to the absence of antiparasitic vaccines and the constant threat of drug resistance,
the development of novel antiparasitic chemotherapies remains of major importance for …

The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …

The pharmacogenetics of antimalarial agents are poorly known, although the application of
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …

One approach to investigate if human genetic variation influences the selection of
Plasmodium falciparum drug resistance is to compare the frequency of resistant infections …

As the common birthplace of all human populations, modern humans have lived longer on
the African continent than in any other geographical region of the world. This long history …

Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a
mechanism to prevent or slow the spread of resistance. This strategy is justified by …

Background The aim of this study was to investigate cytochrome P450 2C8* 2 (CYP2C8* 2)
distribution and allele frequency in three populations from West and East Africa exposed to …

Coordinated global efforts to prevent and control malaria have been a tour-de-force for
public health, but success appears to have reached a plateau in many parts of the world …