The preparation of compounds labelled with deuterium or tritium has become an essential
tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to …

Hydrogen isotope exchange (HIE) has become one of the most studied methods to prepare
deuterated molecules, with the primary focus recently on metal-catalyzed C–H activation …

Hydroxylated (hetero) arenes are valued in many industries as both key constituents of end
products and diversifiable synthetic building blocks. Accordingly, the development of …

The K2CO3/18-crown-6-catalyzed H/D exchange of heretoarenes in high atom% deuterium
incorporation is disclosed. The use of a weak base as a catalyst leads to excellent site …

Aromatic sulfones are the prevailing scaffolds in pharmaceutical and material sciences.
However, compared to their widespread application, the selective deuterium labeling of …

Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the
deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an …

Herein, we report acid/base-controlled and divergent deuteration of N-unsubstituted
imidazoles in an imidazole-selective manner. This protocol enabled the deuteration of not …

Polychlorinated biphenyls are one of the most ubiquitous and harmful environmental
pollutants at present. With the rapid development of mass spectrometry-based analysis …

We report an efficient and easily available transition metal-free catalyst, barium oxide (BaO),
for D/H exchange reaction between pyridine and D2. BaO enables selective deuteration at …

Comprehensive Summary Deuterium labelling possesses wide applications in
pharmaceuticals, chemical science and materials science. Development of efficient …