Background Limited data suggest that higher hemoglobin thresholds for red-cell
transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants …

Iron is an essential micronutrient for early development, being involved in several cellular
processes and playing a significant role in neurodevelopment. Prematurity may impact on …

Necroptosis is generally considered as an inflammatory cell death form. The core regulators
of necroptotic signaling are receptor‐interacting serine–threonine protein kinases 1 (RIPK1) …

BACKGROUND RBC transfusion effectiveness varies due to donor, component, and
recipient factors. Prior studies identified characteristics associated with variation in …

BACKGROUND Blood transfusion is a lifesaving intervention for millions of recipients
worldwide every year. Storing blood makes this possible but also promotes a series of …

Additive solutions are used to limit changes that red blood cells (RBCs) undergo during
storage. Several studies have shown better preservation of glucose and redox metabolism …

Background While previous studies have described the use of blood components in subsets
of children, such as the critically ill, little is known about transfusion practices in hospitalized …

BACKGROUND: Patients with sepsis often exhibit an acute inflammatory response, followed
by an immunosuppressive phase with a poor immune response. However, the underlying …

While differences among donors has long challenged meeting quality standards for the
production of blood components for transfusion, only recently has the molecular basis for …

Background The red blood cell (RBC) storage lesion is a series of morphological, functional,
and metabolic changes that RBCs undergo following collection, processing, and refrigerated …