Emerging roles of liquid-liquid phase separation in liver innate immunity

X Zhang, Z Yang, C Fu, R Yao, H Li, F Peng… - Cell Communication and …, 2024 - Springer
Biomolecular condensates formed by liquid-liquid phase separation (LLPS) have become
an extensive mechanism of macromolecular metabolism and biochemical reactions in cells …

cGAS-STING: mechanisms and therapeutic opportunities

M Zhang, C Wu, D Lu, X Wang, G Shang - Science China Life Sciences, 2025 - Springer
The cGAS-STING pathway plays a crucial role in the innate immune system by detecting
mislocalized double-stranded DNA (dsDNA) in the cytoplasm and triggering downstream …

Tandem‐Controlled Dynamic DNA Assembly Enables Temporally‐Selective Orthogonal Regulation of cGAS–STING Stimulation

X Li, F Yu, L Li - Angewandte Chemie International Edition, 2024 - Wiley Online Library
Despite advances in the controlled reconfiguration of DNA structures for biological
applications, the dearth of strategies that allow for orthogonal regulation of immune …

Targeting protein condensation in cGAS‐STING signaling pathway

Y Li, D Zhao, D Chen, Q Sun - BioEssays, 2024 - Wiley Online Library
The cGAS‐STING signaling pathway plays a pivotal role in sensing cytosolic DNA and
initiating innate immune responses against various threats, with disruptions in this pathway …

Proteolysis-targeting vaccines (PROTAVs) for robust combination immunotherapy of melanoma

Q Wang, T Su, F Cheng, S Zhou, X Liu, M Wang, Y Xu… - bioRxiv, 2024 - biorxiv.org
Protein/peptide subunit vaccines are promising to promote the tumor therapeutic efficacy of
immune checkpoint blockade (ICB). However, current protein/peptide vaccines elicit limited …