Understanding the gut–brain axis and its therapeutic implications for neurodegenerative disorders

Y Zheng, L Bonfili, T Wei, AM Eleuteri - Nutrients, 2023 - mdpi.com
The gut–brain axis (GBA) is a complex bidirectional communication network connecting the
gut and brain. It involves neural, immune, and endocrine communication pathways between …

Inflammatory bowel disease and risk of Parkinson's disease: Evidence from a meta-analysis of 14 studies involving more than 13.4 million individuals

H Li, C Zhang, K Zhang, Y Liu, X Peng, Q Zong - Frontiers in Medicine, 2023 - frontiersin.org
Background The relationship between inflammatory bowel disease (IBD) and the risk of
Parkinson's Disease (PD) has been investigated in several epidemiological studies …

Does inflammation play a major role in the pathogenesis of Alzheimer's disease?

B Wiatrak, P Jawień, A Szeląg… - NeuroMolecular …, 2023 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease leading to dementia for which no
effective medicine exists. Currently, the goal of therapy is only to slow down the inevitable …

Risk of common neurological disorders in adult patients with inflammatory bowel disease: a systematic review and meta-analysis

M Zamani, F Ebrahimtabar… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Several studies investigated the risks of neurological conditions in patients with
inflammatory bowel disease (IBD), with some variability in findings. We aimed to perform a …

The Interface between inflammatory bowel disease, Neuroinflammation, and neurological disorders

GE Hey, V Vedam-Mai, M Beke, M Amaris… - Seminars in …, 2023 - thieme-connect.com
Inflammatory Bowel Disease (IBD) is a complex, chronic inflammatory condition affecting the
gastrointestinal tract. IBD has been associated with a variety of neurologic manifestations …

[HTML][HTML] Metabolic and Immune System Dysregulation: Unraveling the Connections between Alzheimer's Disease, Diabetes, Inflammatory Bowel Diseases, and …

J Doroszkiewicz, J Mroczko, I Winkel… - Journal of Clinical …, 2024 - mdpi.com
Alzheimer's disease (AD), diabetes mellitus (DM), inflammatory bowel diseases (IBD), and
rheumatoid arthritis (RA) are chronic conditions affecting millions globally. Despite differing …

Ingestion of Lacticaseibacillus Rhamnosus Fmb14 prevents depression-like behavior and brain neural activity via the microbiota–gut–brain axis in colitis mice

H Zhao, X Chen, L Zhang, C Tang, F Meng, L Zhou… - Food & Function, 2023 - pubs.rsc.org
Large preclinical evidence suggested that colitis was one of the risk factors for depression
and probiotics were effective therapeutic agents to prevent the disease. The effect of …

Inflammation, autoimmunity and neurodegenerative diseases, therapeutics and beyond

JV Garmendia, CV De Sanctis, V Das… - Current …, 2024 - benthamdirect.com
Neurodegenerative disease (ND) incidence has recently increased due to improved life
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …

Altered secretion, constitution, and functional properties of the gastrointestinal mucus in a rat model of sporadic alzheimer's disease

J Homolak, J De Busscher… - ACS Chemical …, 2023 - ACS Publications
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is
currently unknown whether GI alterations arise as a consequence of central nervous system …

Association of inflammatory bowel disease and related medication exposure with risk of Alzheimer's disease: An updated meta-analysis

Y Xing, P Li, Y Jia, K Zhang, M Liu… - Frontiers in Aging …, 2023 - frontiersin.org
Background Chronic systemic inflammation may be associated with neurocognitive decline,
but the relationships between inflammatory bowel disease and related medications and the …