Translating the 4-letter code of RNA into the 22-letter alphabet of proteins is a central feature
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …

The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous
occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic …

Aminoacyl–transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct
amino acid to its corresponding tRNA during translation of the genetic code, are proven …

The ability to introduce fluorophores selectively into proteins provides a powerful tool to
study protein structure, dynamics, localization, and biomolecular interactions both in vitro …

The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Oxidative stress arises from excessive reactive oxygen species (ROS) and affects organisms
of all three domains of life. Here we present a previously unknown pathway through which …

Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A
growing number of bacterial isolates responsible for these infections are resistant to …

Combinatorial libraries of nonbiological polymers and drug-like peptides could in principle
be synthesized from unnatural amino acids by exploiting the broad substrate specificity of …

The molecular mechanisms underlying thiol-based redox control are poorly defined.
Disulfide bonds between Cys residues are commonly thought to confer extra rigidity and …

We genetically encoded the photocaged amino acid 4, 5-dimethoxy-2-nitrobenzylserine
(DMNB-Ser, 1) in Saccharomyces cerevisiae in response to the amber nonsense codon …