Novel 1, 2, 4-oxadiazole derivatives in drug discovery
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
[HTML][HTML] A review on synthetic account of 1, 2, 4-oxadiazoles as anti-infective agents
TM Dhameliya, SJ Chudasma, TM Patel, BP Dave - Molecular Diversity, 2022 - Springer
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …
Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR
Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …
Different inflammatory mediators are released during an inflammation responsible for acute …
[HTML][HTML] Synthesis, spectral characterization, antimicrobial evaluation studies and cytotoxic activity of some transition metal complexes with tridentate (N, N, O) donor …
HAK Kyhoiesh, KJ Al-Adilee - Results in Chemistry, 2021 - Elsevier
A new azo dye ligand 2-[2'-(6-methoxybenzothiazolyl) azo]-4-ethoxyphenol (6-MBTAEP)
was prepared by reacting a diazonium chloride salt solution of 2-amino-6-methoxy …
was prepared by reacting a diazonium chloride salt solution of 2-amino-6-methoxy …
Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)
SMI Mahboubi Rabbani, A Zarghi - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The
products of this enzyme could play a major role as the mediators of the inflammatory …
products of this enzyme could play a major role as the mediators of the inflammatory …
Modern approaches to the synthesis and transformations of practically valuable benzothiazole derivatives
LV Zhilitskaya, BA Shainyan, NO Yarosh - Molecules, 2021 - mdpi.com
The review is devoted to modern trends in the chemistry of 2-amino and 2-mercapto
substituted benzothiazoles covering the literature since 2015. The reviewed heterocycles …
substituted benzothiazoles covering the literature since 2015. The reviewed heterocycles …
New pyrimidine-5-carbonitriles as COX-2 inhibitors: design, synthesis, anticancer screening, molecular docking, and in silico ADME profile studies
Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …
In silico anti-inflammatory activity evaluation of some bioactive compound from ficus religiosa through molecular docking approach
This tree generally is used as traditional medicine for several ailments. In this research, the
In Silico approach using molecular docking has been applied to 11 compounds from the …
In Silico approach using molecular docking has been applied to 11 compounds from the …
Structure-based screening for the discovery of 1, 2, 4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid …
M Potenza, M Sciarretta, MG Chini, A Saviano… - European Journal of …, 2021 - Elsevier
The multiple inhibition of biological targets involved in pro-inflammatory eicosanoid
biosynthesis represents an innovative strategy for treating inflammatory disorders in light of …
biosynthesis represents an innovative strategy for treating inflammatory disorders in light of …
Design, synthesis and biological evaluation of 2 (((5‐aryl‐1, 2, 4‐oxadiazol‐3‐yl) methyl) thio) benzo [d] oxazoles: new antiinflammatory and antioxidant agents
The oxadiazole linked benzoxazoles derivatives were designed using scaffold hopping
approach and their molecular level interactions with both isoforms of cyclooxygenases, C …
approach and their molecular level interactions with both isoforms of cyclooxygenases, C …