Advancing the logic of chemical synthesis: C− H activation as strategic and tactical disconnections for C− C bond construction

NYS Lam, K Wu, JQ Yu - Angewandte Chemie, 2021 - Wiley Online Library
The design of synthetic routes by retrosynthetic logic is decisively influenced by the
transformations available. Transition‐metal‐catalyzed C− H activation has emerged as a …

Transition metal‐catalyzed enantioselective C− H functionalization via chiral transient directing group strategies

G Liao, T Zhang, ZK Lin, BF Shi - … Chemie International Edition, 2020 - Wiley Online Library
Transition metal‐catalyzed enantioselective functionalization of C− H bond, the most
abundant functionality in organic molecules, has emerged as an expedient synthetic …

Transition‐metal‐catalyzed carboxylation reactions with carbon dioxide

A Tortajada, F Juliá‐Hernández… - Angewandte Chemie …, 2018 - Wiley Online Library
Driven by the inherent synthetic potential of CO2 as an abundant, inexpensive and
renewable C1 chemical feedstock, the recent years have witnessed renewed interest in …

Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

Y Ping, Y Li, J Zhu, W Kong - … Chemie International Edition, 2019 - Wiley Online Library
The enantioselective synthesis of molecules containing quaternary stereocenters is a field of
intense research interest and development. Among the known organic transformations …

A simple and versatile amide directing group for C− H functionalizations

RY Zhu, ME Farmer, YQ Chen… - Angewandte Chemie …, 2016 - Wiley Online Library
Achieving selective C− H activation at a single and strategic site in the presence of multiple
C− H bonds can provide a powerful and generally useful retrosynthetic disconnection. In this …

The Cross‐Dehydrogenative Coupling of C H Bonds: A Versatile Strategy for C C Bond Formations

SA Girard, T Knauber, CJ Li - … Chemie International Edition, 2014 - Wiley Online Library
Over the last decade, substantial research has led to the introduction of an impressive
number of efficient procedures which allow the selective construction of C C bonds by …

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

G Rouquet, N Chatani - Angewandte Chemie International …, 2013 - Wiley Online Library
C H bonds are ubiquitous in organic compounds. It would, therefore, appear that direct
functionalization of substrates by activation of C H bonds would eliminate the multiple …

Metal‐Catalyzed Annulations through Activation and Cleavage of C− H Bonds

M Gulías, JL Mascareñas - Angewandte Chemie International …, 2016 - Wiley Online Library
The exponential increase in the number of catalytic transformations that involve a metal‐
promoted activation of hitherto considered inert C− H bonds is promoting a fundamental …

C H Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

J Yamaguchi, AD Yamaguchi… - Angewandte Chemie …, 2012 - Wiley Online Library
The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

Palladium‐catalyzed cross‐coupling: a historical contextual perspective to the 2010 Nobel Prize

CCC Johansson Seechurn, MO Kitching… - Angewandte Chemie …, 2012 - Wiley Online Library
Abstract In 2010, Richard Heck, Ei‐ichi Negishi, and Akira Suzuki joined the prestigious
circle of Nobel Laureate chemists for their roles in discovering and developing highly …