The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

Defining neuronal cell types and their associated biophysical and synaptic diversity has
become an important goal in neuroscience as a mechanism to create comprehensive brain …

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated …

Although neuronal subtypes display unique synaptic organization and function, the
underlying transcriptional differences that establish these features are poorly understood. To …

Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …

Neural circuit function depends on the pattern of synaptic connections between neurons and
the strength of those connections. Synaptic strength is determined by both postsynaptic …

Neurotransmitter release is stabilized by homeostatic plasticity. Presynaptic homeostatic
potentiation (PHP) operates on timescales ranging from minute-to life-long adaptations and …

Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …

Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within
stable physiological ranges. To study this process, we investigated Drosophila endophilin …

Synaptic vesicle (SV) release probability (P r) is a key presynaptic determinant of synaptic
strength established by cell-intrinsic properties and further refined by plasticity. To …