HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …

Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

Severe acute respiratory syndrome coronavirus‐2 (SARS CoV‐2) is the causative agent of
the coronavirus disease‐2019 (COVID‐19) pandemic. Coronaviruses enter cells via fusion …

Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design
and have dramatically improved AIDS therapy. Analysis of the structures and activities of …

Drugs that target the main protease (Mpro) of SARS-CoV-2 are effective therapeutics that
have entered clinical use. Wide-scale use of these drugs will apply selection pressure for the …

In this study, we introduce a fast and reliable rescoring scheme for docked complexes based
on a semiempirical quantum mechanical PM6-DH2 method. The method utilizes a PM6 …

The design, development and clinical success of HIV protease inhibitors represent one of
the most remarkable achievements of molecular medicine. This review describes all nine …

Although many protein variants have properties similar to their corresponding wild-type
structures, the replacement of a single amino acid often produces dramatic changes in …

A significant number of antiviral agents used in clinical practice are amino acids, short
peptides, or peptidomimetics. Among them, several HIV protease inhibitors (eg lopinavir …

The escape mutant of HIV-1 protease (PR) containing 20 mutations (PR20) undergoes
efficient polyprotein processing even in the presence of clinical protease inhibitors (PIs) …