Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …

The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …

It is with great pleasure that I write this foreword and introduction to this Special Issue
dedicated to the protective actions of the pro-resolving mediators and edited by my …

A new genus of specialized pro-resolving mediators (SPM) which include several families of
distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in …

Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Because inflammation is appreciated as a unifying basis of many widely occurring diseases,
the mechanisms involved in its natural resolution are of considerable interest. Using …

Accurate quantitative analysis of endogenous analytes is essential for several clinical and
non-clinical applications. LC–MS/MS is the technique of choice for quantitative analyses …

Inflammation is an essential physiological defence mechanism, but prolonged or excessive
inflammation can cause disease. Indeed, unresolved systemic and adipose tissue …

Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the
initiation and resolution of inflammation. These compounds, also referred to as lipid …