Atoh1 (also known as Math1, Hath1, and Cath1 in mouse, human, and chicken, respectively)
is a proneural basic helix–loop–helix (bHLH) transcription factor that is required in a variety …

Few therapies for Meniere's disease or other forms of peripheral vertigo have undergone
such dramatic reappraisals as has the use of intratympanic aminoglycosides. Soon after its …

The progression of recovery of the vestibular sensory epithelia of guinea pigs after
gentamicin‐induced hair cell injury was assessed quantitatively and qualitatively …

Hair cell death was examined in cultured explants of vestibular organs from mature guinea
pigs and gerbils. The effects of gentamicin were compared with those of staurosporine, a …

Whereas most epithelial tissues turn-over and regenerate after a traumatic lesion, this
restorative ability is diminished in the sensory epithelia of the inner ear; it is absent in the …

Gentamicin is toxic to vestibular hair cells, but its effects on vestibular afferents have not
been defined. We treated anesthetized chinchillas with one injection of gentamicin (26.7 …

The 3-dimensional angular vestibulo-ocular reflexes (AVOR) elicited by rapid rotary head
thrusts were studied in 17 subjects with unilateral Ménière's disease before and 2–10 weeks …

Intratympanic (IT) gentamicin injections are effective in the control of episodic vertigo due to
Ménière's disease. Histological studies in animals have found that the loss of type I …

Loss of the mechanosensory hair cells in the auditory and vestibular organs leads to hearing
and balance deficits. To investigate initial, in vivo events in aminoglycoside‐induced hair …

To utilize the rapidly accumulating genetic information for developing new therapeutic
technologies for inner ear disease, it is necessary to design technologies for expressing …