Measurable residual disease and decision-making in multiple myeloma

BA Derman, R Fonseca - Hematology/Oncology Clinics, 2024 - hemonc.theclinics.com
Measurable (or minimal) residual disease (MRD) in multiple myeloma (MM) refers to low
levels of myeloma cells detectable using advanced diagnostics. MRD testing is evolving …

Current and Future PET imaging for multiple myeloma

M Ishibashi, M Takahashi, T Yamaya, Y Imai - Life, 2023 - mdpi.com
Positron emission tomography (PET) is an imaging modality used for the noninvasive
assessment of tumor staging and response to therapy. PET with 18F labeled …

Minimal residual disease detection by next-generation sequencing of different immunoglobulin gene rearrangements in pediatric B-ALL

H Chen, M Gu, J Liang, H Song, J Zhang, W Xu… - Nature …, 2023 - nature.com
While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in
minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has …

Prognostic value of early bone marrow MRD status in CAR-T therapy for myeloma

R Bansal, M Baksh, JT Larsen, MA Hathcock… - Blood cancer …, 2023 - nature.com
Bone marrow (BM) assessment of minimal residual disease (MRD) is prognostic for survival
in multiple myeloma (MM). BM is still hypocellular at month 1 post CAR-T, thus the value of …

Upfront or Deferred Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma in the Era of Triplet and Quadruplet Induction and Minimal Residual …

CC Mo, MA Hartley-Brown, S Midha, PG Richardson - Cancers, 2023 - mdpi.com
Simple Summary Patients who are diagnosed with multiple myeloma are given an initial
sequence of treatments that usually, for those who are young and fit enough, includes high …

Symptomatic Myeloma: PET, Whole-Body MR Imaging with Diffusion-Weighted Imaging or Both

A Rossi, A Cattabriga, D Bezzi - PET clinics, 2024 - pet.theclinics.com
The diagnosis of multiple myeloma (MM) is based on a wide range of features (“CRAB
criteria”) and includes hypercalcemia (C), renal failure (R), anemia (A), and the presence of …

How do we image patients with multiple myeloma and precursor states?

R Chakraborty, J Hillengass… - British Journal of …, 2023 - Wiley Online Library
Advances in morphological and functional imaging have led to superior detection of early
bone disease, bone marrow infiltration, paramedullary and extramedullary involvement in …

Clinical factors associated with autologous stem cell transplantation outcomes in multiple myeloma: upfront transplant with MEL200 remains the standard of care

B Bostankolu Değirmenci, ZA Yegin, ÜÖ Akdemir… - Annals of …, 2024 - Springer
Autologous stem cell transplantation (ASCT) remains the mainstay of the treatment in newly
diagnosed transplant-eligible multiple myeloma (MM) patients. This retrospective study was …

[HTML][HTML] Matrine induces autophagic cell death by triggering ROS/AMPK/mTOR axis and apoptosis in multiple myeloma

X Li, J Zhou, Y Ling, Y Tan, J Zhang, X Wang… - Biomedicine & …, 2024 - Elsevier
Despite significant advancements in multiple myeloma (MM) treatment in recent years, most
patients will eventually develop resistance or experience relapse. Matrine, a primary active …

Minimal Residual Disease-Adapted Therapy in Multiple Myeloma: Current Evidence and Opinions

M Meseha, J Hoffman, D Kazandjian… - Current Oncology …, 2024 - Springer
MRD transcends traditional response assessments by providing a window into disease-
treatment interaction over time. As a strong patient-level surrogate, MRD has limited current …